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Hypersensitivity, pregnancy, estrogen depending malignant neoplasms, unusual or undiagnosed genital and uterine bleeding, thrombophlebitis or thromboembolic disease in active phase (excluding treatment of breast and prostate cancer). Carefulness should be exercised in patients with thrombophlebitis, thrombosis or thromboembolism (during takeing of estrogens in history); family hyperlipoproteinemia, pancreatitis, endometriosis, gallbladder r disease in history, severe liver failure, jaundice, hepatic porphyria, hypercalcemia associated with metastases in bones caused by a breast cancer. Only for treatment of breast and prostate cancer: diseases of the coronary or cerebral vessels, active thrombophlebitis or thromboembolic disease.
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